Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness

Inhibition of integrin alpha5beta1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin alpha5beta1 by backbone replacement of known alphavbeta1 integrin inhibitors. These integrin alpha5beta1...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Sundaram, Aparna, Chen, Chun, Isik Reed, Nilgun, Liu, Sean, Yeon, Seul Ki, McIntosh, Joel, Tang, You-Zhi, Yang, Hyunjun, Adler, Marc, Beresis, Richard, Seiple, Ian B., Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700746/
https://ncbi.nlm.nih.gov/pubmed/33007395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127578
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