Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness

Inhibition of integrin alpha5beta1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin alpha5beta1 by backbone replacement of known alphavbeta1 integrin inhibitors. These integrin alpha5beta1...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Sundaram, Aparna, Chen, Chun, Isik Reed, Nilgun, Liu, Sean, Yeon, Seul Ki, McIntosh, Joel, Tang, You-Zhi, Yang, Hyunjun, Adler, Marc, Beresis, Richard, Seiple, Ian B., Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700746/
https://ncbi.nlm.nih.gov/pubmed/33007395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127578
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