Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness

Inhibition of integrin alpha5beta1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin alpha5beta1 by backbone replacement of known alphavbeta1 integrin inhibitors. These integrin alpha5beta1...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Sundaram, Aparna, Chen, Chun, Isik Reed, Nilgun, Liu, Sean, Yeon, Seul Ki, McIntosh, Joel, Tang, You-Zhi, Yang, Hyunjun, Adler, Marc, Beresis, Richard, Seiple, Ian B., Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700746/
https://ncbi.nlm.nih.gov/pubmed/33007395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127578
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