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Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness
Inhibition of integrin alpha5beta1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin alpha5beta1 by backbone replacement of known alphavbeta1 integrin inhibitors. These integrin alpha5beta1...
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| Publicado en: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7700746/ https://ncbi.nlm.nih.gov/pubmed/33007395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127578 |
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