Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly understood. PDGF receptor β (PDGFRβ) is highly expressed in activated pericytes, a main source of fibroblasts. Studies using a PDGFRβ promoter–drive...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Chang, Yongen, Lau, Wei Ling, Jo, Hyunil, Tsujino, Kazuyuki, Gewin, Leslie, Reed, Nilgun Isik, Atakilit, Amha, Nunes, Ane Claudia Fernandes, DeGrado, William F., Sheppard, Dean
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2017
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491273/
https://ncbi.nlm.nih.gov/pubmed/28220032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050585
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