Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly understood. PDGF receptor β (PDGFRβ) is highly expressed in activated pericytes, a main source of fibroblasts. Studies using a PDGFRβ promoter–drive...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Chang, Yongen, Lau, Wei Ling, Jo, Hyunil, Tsujino, Kazuyuki, Gewin, Leslie, Reed, Nilgun Isik, Atakilit, Amha, Nunes, Ane Claudia Fernandes, DeGrado, William F., Sheppard, Dean
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Brief Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491273/
https://ncbi.nlm.nih.gov/pubmed/28220032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050585
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