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Using Thioamides to Site-Specifically Interrogate the Dynamics of Hydrogen Bond Formation in β-Sheet Folding
Thioamides are sterically almost identical to their oxoamide counterparts, but are weaker hydrogen bond acceptors in comparison. Therefore, thioamide amino acids are excellent candidates for perturbing the energetics of backbone-backbone hydrogen bonds in proteins and hence should be useful in eluci...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3354031/ https://ncbi.nlm.nih.gov/pubmed/22540162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja301681v |
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