Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

[Image: see text] Influenza virus infections lead to numerous deaths and millions of hospitalizations each year. One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza viruses, which comprise several strains with variable susceptibility to antiviral dr...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wu, Yibing, Canturk, Belgin, Jo, Hyunil, Ma, Chunlong, Gianti, Eleonora, Klein, Michael L., Pinto, Lawrence H., Lamb, Robert A., Fiorin, Giacomo, Wang, Jun, DeGrado, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286326/
https://ncbi.nlm.nih.gov/pubmed/25470189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja508461m
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