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Development of α-Helical Calpain Probes by Mimicking a Natural Protein-Protein Interaction
We have designed a highly specific inhibitor of calpain by mimicking a natural protein-protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this goal we established a new method of stabilizing an α-helix in a small peptide by screening twenty-four commercially avai...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523126/ https://ncbi.nlm.nih.gov/pubmed/22998171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307599z |
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