Apogossypol Derivatives as Pan-active Inhibitors of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins

Guided by nuclear magnetic resonance (NMR) binding assays and computational docking studies, a series of 5, 5′ substituted Apogossypol derivatives was synthesized that resulted in potent pan-active inhibitors of anti-apoptotic Bcl-2 family proteins. Compound 8r inhibits the binding of BH3 peptides t...

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Bibliografiske detaljer
Main Authors: Wei, Jun, Kitada, Shinichi, Rega, Michele F., Stebbins, John L., Zhai, Dayong, Cellitti, Jason, Yuan, Hongbin, Emdadi, Aras, Dahl, Russell, Zhang, Ziming, Yang, Li, Reed, John C., Pellecchia, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747480/
https://ncbi.nlm.nih.gov/pubmed/19555126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900472s
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