BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins

In our continued attempts to identify novel and effective pan-Bcl-2 antagonists, we have recently reported a series of compound 2 (Apogossypol) derivatives, resulting in the chiral compound 4 (8r). We report here on synthesis and evaluation on its optically pure individual isomers. Compound 11 (BI-9...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wei, Jun, Stebbins, John L., Kitada, Shinichi, Dash, Rupesh, Placzek, William, Rega, Michele F., Wu, Bainan, Cellitti, Jason, Zhai, Dayong, Yang, Li, Dahl, Russell, Fisher, Paul B., Reed, John C., Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880850/
https://ncbi.nlm.nih.gov/pubmed/20443627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1001265
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados