Apogossypol Derivatives as Antagonists of Anti-apoptotic Bcl-2 Family Proteins

Guided by a combination of nuclear magnetic resonance binding assays and computational docking studies, we synthesized a library of 5, 5’ substituted Apogossypol derivatives as potent Bcl-X(L) antagonists. Each compound was subsequently tested for its ability to inhibit Bcl-X(L) in an in vitro fluor...

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Detalhes bibliográficos
Main Authors: Wei, Jun, Kitada, Shinichi, Rega, Michele F., Emdadi, Aras, Yuan, Hongbin, Cellitti, Jason, Stebbins, John L., Zhai, Dayong, Sun, Jiazhi, Yang, Li, Dahl, Russell, Zhang, Ziming, Wu, Bainan, Wang, Si, Reed, Tyler A., Wang, Hong-Gang, Lawrence, Nicholas, Sebti, Said, Reed, John C., Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750823/
https://ncbi.nlm.nih.gov/pubmed/19372563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1050
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