Derivatization of Agelastatin A Leading to Bioactive Analogs and a Trifunctional Probe

(−)-Agelastatin A (AglA, 1), a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, possesses a unique tetracyclic structure and is one of the most potent anticancer PAIs isolated to date. In efforts to expand the SAR of these agents and delineate sites that tolerate modification while...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Jouanneau, Morgan, McClary, Brandon, Reyes, Jeremy C., Chen, Rong, Chen, Yuling, Plunkett, William, Cheng, Xin, Milinichik, Andrew Z., Albone, Earl F., Liu, Jun O., Romo, Daniel
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522753/
https://ncbi.nlm.nih.gov/pubmed/26951751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.051
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