Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells

Por Xie, Chun, Li, Ying, Li, Lan-Lan, Fan, Xing-Xing, Wang, Yu-Wei, Wei, Chun-Li, Liu, Liang, Leung, Elaine Lai-Han, Yao, Xiao-Jun
Publicado no Front Pharmacol (2017)

A practical Java tool for small-molecule compound appraisal

Por Amani, Parisa, Sneyd, Todd, Preston, Sarah, Young, Neil D, Mason, Lyndel, Bailey, Ulla-Maja, Baell, Jonathan, Camp, David, Gasser, Robin B, Gorse, Alain-Dominique, Taylor, Paul, Hofmann, Andreas
Publicado no J Cheminform (2015)

Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential

Por Ma, Jing, Salamoun, Joseph, Wipf, Peter, Edwards, Robert, Van Houten, Bennett, Qian, Wei
Publicado no Oncotarget (2017)

Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits

Por Lee, Lan-Sook, Cho, Chang-Won, Hong, Hee-Do, Lee, Young-Chul, Choi, Ung-Kyu, Kim, Young-Chan
Publicado no Molecules (2013)

Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound

Por Liu, Jiyuan, Tian, Zhen, Zhou, Nan, Liu, Xueying, Liao, Chenyi, Lei, Beilei, Li, Jianing, Zhang, Shengyong, Chen, Hui
Publicado no Oncotarget (2017)

Synthesis of Cyclic 1,3-Diols as Scaffolds for Spatially Directed Libraries

Por Singh, Gurpreet, Aubé, Jeffrey
Publicado no Org Biomol Chem (2016)

Local epigenetic reprograming induced by G-quadruplex ligands

Por Guilbaud, Guillaume, Murat, Pierre, Recolin, Bénédicte, Campbell, Beth C., Maiter, Ahmed, Sale, Julian E., Balasubramanian, Shankar
Publicado no Nat Chem (2017)

Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

Por Mognol, Giuliana P., González-Avalos, Edahí, Ghosh, Srimoyee, Spreafico, Roberto, Gudlur, Aparna, Rao, Anjana, Damoiseaux, Robert, Hogan, Patrick G.
Publicado no Proc Natl Acad Sci U S A (2019)

NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3

Por Kim, Byung-Hak, Jee, Jun-Goo, Yin, Chang-Hong, Sandoval, Claudio, Jayabose, Somasundaram, Kitamura, Daisuke, Bach, Erika A, Baeg, Gyeong-Hun
Publicado em 2010

A new ChEMBL dataset for the similarity-based target fishing engine FastTargetPred: Annotation of an exhaustive list of linear tetrapeptides

Por Shivalika Tanwar, Patrick Auberger, Germain Gillet, Mario DiPaola, Katya Tsaioun, Bruno O. Villoutreix
Publicado em 2022-06-01

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

Por Huryn, Donna M., Brodsky, Jeffrey L., Brummond, Kay M., Chambers, Peter G., Eyer, Benjamin, Ireland, Alex W., Kawasumi, Masaoki, LaPorte, Matthew G., Lloyd, Kayla, Manteau, Baptiste, Nghiem, Paul, Quade, Bettina, Seguin, Sandlin P., Wipf, Peter
Publicado em 2011

Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors

Por Deng, Xiaobing, Zhang, Xiaoling, Tang, Bo, Liu, Hongbo, Shen, Qi, Liu, Ying, Lai, Luhua
Publicado no Front Chem (2018)

Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

Por Yongye, Austin B., Vivoli, Mirella, Lindberg, Iris, Appel, Jon R., Houghten, Richard A., Martinez-Mayorga, Karina
Publicado em 2013

Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors

Por Li, Zhong-Hua, Liu, Xue-Qi, Geng, Peng-Fei, Suo, Feng-Zhi, Ma, Jin-Lian, Yu, Bin, Zhao, Tao-Qian, Zhou, Zhao-Qing, Huang, Chen-Xi, Zheng, Yi-Chao, Liu, Hong-Min
Publicado no ACS Med Chem Lett (2017)

The First Negative Allosteric Modulator for Dopamine D(2) and D(3) Receptors, SB269652 May Lead to a New Generation of Antipsychotic Drugs

Por Rossi, Mario, Fasciani, Irene, Marampon, Francesco, Maggio, Roberto, Scarselli, Marco
Publicado no Mol Pharmacol (2017)

Small Molecule Cardiogenol C Upregulates Cardiac Markers and Induces Cardiac Functional Properties in Lineage-Committed Progenitor Cells

Por Mike, Agnes K., Koenig, Xaver, Koley, Moumita, Heher, Philipp, Wahl, Gerald, Rubi, Lena, Schnürch, Michael, Mihovilovic, Marko D., Weitzer, Georg, Hilber, Karlheinz
Publicado no Cell Physiol Biochem (2014)

Cogging Torque Reduction Based on a New Pre-Slot Technique for a Small Wind Generator

Por Miguel García-Gracia, Ángel Jiménez Romero, Jorge Herrero Ciudad, Susana Martín Arroyo
Publicado em 2018-11-01

A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor

Por Craik, Charles S., Shahian, Tina
Publicado em 2012

Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics.

Por Jamal Chauhan, Steven Cardinale, Lei Fang, Jing Huang, Steven M Kwasny, M Ross Pennington, Kelly Basi, Robert diTargiani, Benedict R Capacio, Alexander D MacKerell, Timothy J Opperman, Steven Fletcher, Erik P H de Leeuw
Publicado em 2016-01-01

Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations

Por Choi, Jaesung P., Wang, Rui, Yang, Xi, Wang, Xian, Wang, Lu, Ting, Ka Ka, Foley, Matthew, Cogger, Victoria, Yang, Zhuo, Liu, Feng, Han, Zhiming, Liu, Renjing, Baell, Jonathan, Zheng, Xiangjian
Publicado no Sci Adv (2018)