NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3

BACKGROUND: Human or animals lacking either JAK3 or the common gamma chain (γc) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogene...

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Detalhes bibliográficos
Main Authors: Kim, Byung-Hak, Jee, Jun-Goo, Yin, Chang-Hong, Sandoval, Claudio, Jayabose, Somasundaram, Kitamura, Daisuke, Bach, Erika A, Baeg, Gyeong-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830973/
https://ncbi.nlm.nih.gov/pubmed/20149240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-36
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