MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

To identify JAK/STAT signaling inhibitors, we performed a cell-based high throughput screening using a plant extract library and identified Nb-(α-hydroxynaphthoyl)serotonin called MS-1020 as a novel JAK3 inhibitor. MS-1020 potently inhibited persistently-active STAT3 in a cell type-specific manner....

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Detalhes bibliográficos
Main Authors: Kim, Byung Hak, Oh, Sei-Ryang, Yin, Chang-Hong, Lee, Sangku, Kim, Eun-Ah, Kim, Min-Seok, Sandoval, Claudio, Jayabose, Somasundaram, Bach, Erika A., Lee, Hyeong-Kyu, Baeg, Gyeong-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034357/
https://ncbi.nlm.nih.gov/pubmed/19793252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07925.x
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