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NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3
BACKGROUND: Human or animals lacking either JAK3 or the common gamma chain (γc) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogene...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830973/ https://ncbi.nlm.nih.gov/pubmed/20149240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-36 |
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