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Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important target of immune modulation. NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anerg...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Mognol, Giuliana P., González-Avalos, Edahí, Ghosh, Srimoyee, Spreafico, Roberto, Gudlur, Aparna, Rao, Anjana, Damoiseaux, Robert, Hogan, Patrick G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525529/
https://ncbi.nlm.nih.gov/pubmed/31019078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820604116
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