Exhaustion-associated regulatory regions in CD8(+) tumor-infiltrating T cells

T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TI...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mognol, Giuliana P., Spreafico, Roberto, Wong, Victor, Scott-Browne, James P., Togher, Susan, Hoffmann, Alexander, Hogan, Patrick G., Rao, Anjana, Trifari, Sara
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380094/
https://ncbi.nlm.nih.gov/pubmed/28283662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620498114
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