Exhaustion-associated regulatory regions in CD8(+) tumor-infiltrating T cells

T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TI...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mognol, Giuliana P., Spreafico, Roberto, Wong, Victor, Scott-Browne, James P., Togher, Susan, Hoffmann, Alexander, Hogan, Patrick G., Rao, Anjana, Trifari, Sara
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380094/
https://ncbi.nlm.nih.gov/pubmed/28283662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620498114
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