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Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important target of immune modulation. NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anerg...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525529/ https://ncbi.nlm.nih.gov/pubmed/31019078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820604116 |
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