Selective inhibition of calcineurin-NFAT signaling by blocking protein–protein interaction with small organic molecules

Transient or reversible protein–protein interactions are commonly used to ensure efficient targeting of signaling enzymes to their cellular substrates. These interactions include direct binding to substrate, interaction with an accessory or scaffold protein, and positioning at subcellular locations...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Roehrl, Michael H. A., Kang, Sunghyun, Aramburu, José, Wagner, Gerhard, Rao, Anjana, Hogan, Patrick G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15131267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401835101
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