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Selective inhibition of calcineurin-NFAT signaling by blocking protein–protein interaction with small organic molecules

Transient or reversible protein–protein interactions are commonly used to ensure efficient targeting of signaling enzymes to their cellular substrates. These interactions include direct binding to substrate, interaction with an accessory or scaffold protein, and positioning at subcellular locations...

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Hlavní autoři: Roehrl, Michael H. A., Kang, Sunghyun, Aramburu, José, Wagner, Gerhard, Rao, Anjana, Hogan, Patrick G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC419644/
https://ncbi.nlm.nih.gov/pubmed/15131267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401835101
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