Selective inhibition of calcineurin-NFAT signaling by blocking protein–protein interaction with small organic molecules

Transient or reversible protein–protein interactions are commonly used to ensure efficient targeting of signaling enzymes to their cellular substrates. These interactions include direct binding to substrate, interaction with an accessory or scaffold protein, and positioning at subcellular locations...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Roehrl, Michael H. A., Kang, Sunghyun, Aramburu, José, Wagner, Gerhard, Rao, Anjana, Hogan, Patrick G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2004
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15131267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401835101
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