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Structure of the calcineurin-NFAT complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

The phosphatase calcineurin (Cn) plays pivotal roles in many physiological processes, including cell proliferation, development, and apoptosis. Most prominently, Cn dephosphorylates multiple residues of nuclear factors of activated T-cells (NFATs). It jointly translocates with dephosphorylated NFAT...

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Bibliografiske detaljer
Main Authors: Takeuchi, Koh, Roehrl, Michael H. A., Sun, Zhen-Yu J., Wagner, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1989110/
https://ncbi.nlm.nih.gov/pubmed/17502104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.015
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