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Structure of the calcineurin-NFAT complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

The phosphatase calcineurin (Cn) plays pivotal roles in many physiological processes, including cell proliferation, development, and apoptosis. Most prominently, Cn dephosphorylates multiple residues of nuclear factors of activated T-cells (NFATs). It jointly translocates with dephosphorylated NFAT...

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Main Authors: Takeuchi, Koh, Roehrl, Michael H. A., Sun, Zhen-Yu J., Wagner, Gerhard
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1989110/
https://ncbi.nlm.nih.gov/pubmed/17502104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.015
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