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Structure of the calcineurin-NFAT complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates
The phosphatase calcineurin (Cn) plays pivotal roles in many physiological processes, including cell proliferation, development, and apoptosis. Most prominently, Cn dephosphorylates multiple residues of nuclear factors of activated T-cells (NFATs). It jointly translocates with dephosphorylated NFAT...
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| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1989110/ https://ncbi.nlm.nih.gov/pubmed/17502104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.015 |
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