The LxVP and PxIxIT NFAT Motifs Bind Simultaneously to Overlapping Epitopes in Calcineurin’s Catalytic Domain CnA Distant to the Regulatory Domain CnB

The serine/threonine phosphatase calcineurin (Cn) targets the nuclear factors of activated T cells (NFATs) that activate cytokine genes. Calcium influx activates Cn to dephosphorylate multiple serine residues within the ~200 amino acid NFAT regulatory domain, which triggers joint nuclear translocati...

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Bibliographic Details
Main Authors: Gal, Maayan, Li, Shuai, Luna, Rafael E., Takeuchi, Koh, Wagner, Gerhard
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102887/
https://ncbi.nlm.nih.gov/pubmed/24954618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.05.006
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