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The LxVP and PxIxIT NFAT Motifs Bind Simultaneously to Overlapping Epitopes in Calcineurin’s Catalytic Domain CnA Distant to the Regulatory Domain CnB
The serine/threonine phosphatase calcineurin (Cn) targets the nuclear factors of activated T cells (NFATs) that activate cytokine genes. Calcium influx activates Cn to dephosphorylate multiple serine residues within the ~200 amino acid NFAT regulatory domain, which triggers joint nuclear translocati...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102887/ https://ncbi.nlm.nih.gov/pubmed/24954618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.05.006 |
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