Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma

Glioblastoma (GBM) is among the most common and malignant types of primary brain tumors in adult with a dismal prognosis. Although alkylating agents such as temozolomide are widely applied as the first-line treatment for GBM, they often cause chemoresistance and remain ineffective with recurrent GBM...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Liu, Zhenzhen, Li, Hongli, He, Lian, Xiang, Yu, Tian, Chengsen, Li, Can, Tan, Peng, Jing, Ji, Tian, Yanpin, Du, Lupei, Huang, Yun, Han, Leng, Li, Minyong, Zhou, Yubin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430684/
https://ncbi.nlm.nih.gov/pubmed/30639261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.11.009
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