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Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors

[Image: see text] Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation. The aberrant overexpression of LSD1 has been reported to be involved in the progression of certain human malignant tumors. Abrogation of LSD1 with RNAi or small molecule inhibitors may l...

詳細記述

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Li, Zhong-Hua, Liu, Xue-Qi, Geng, Peng-Fei, Suo, Feng-Zhi, Ma, Jin-Lian, Yu, Bin, Zhao, Tao-Qian, Zhou, Zhao-Qing, Huang, Chen-Xi, Zheng, Yi-Chao, Liu, Hong-Min
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2017
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392756/
https://ncbi.nlm.nih.gov/pubmed/28435523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00423
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