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Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors

[Image: see text] Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation. The aberrant overexpression of LSD1 has been reported to be involved in the progression of certain human malignant tumors. Abrogation of LSD1 with RNAi or small molecule inhibitors may l...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Li, Zhong-Hua, Liu, Xue-Qi, Geng, Peng-Fei, Suo, Feng-Zhi, Ma, Jin-Lian, Yu, Bin, Zhao, Tao-Qian, Zhou, Zhao-Qing, Huang, Chen-Xi, Zheng, Yi-Chao, Liu, Hong-Min
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392756/
https://ncbi.nlm.nih.gov/pubmed/28435523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00423
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