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Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharm Sin B
Prif Awduron: Liu, Zhenzhen, Zhao, Taoqian, Li, Zhonghua, Sun, Kai, Fu, Yundong, Cheng, Ting, Guo, Jimin, Yu, Bin, Shi, Xiaojing, Liu, Hongmin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://ncbi.nlm.nih.gov/pubmed/32963944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.12.008
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