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Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...

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Dettagli Bibliografici
Pubblicato in:Acta Pharm Sin B
Autori principali: Liu, Zhenzhen, Zhao, Taoqian, Li, Zhonghua, Sun, Kai, Fu, Yundong, Cheng, Ting, Guo, Jimin, Yu, Bin, Shi, Xiaojing, Liu, Hongmin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://ncbi.nlm.nih.gov/pubmed/32963944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.12.008
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