Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...

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Bibliographic Details
Published in:Acta Pharm Sin B
Main Authors: Liu, Zhenzhen, Zhao, Taoqian, Li, Zhonghua, Sun, Kai, Fu, Yundong, Cheng, Ting, Guo, Jimin, Yu, Bin, Shi, Xiaojing, Liu, Hongmin
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://ncbi.nlm.nih.gov/pubmed/32963944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.12.008
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