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Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Acta Pharm Sin B
Κύριοι συγγραφείς: Liu, Zhenzhen, Zhao, Taoqian, Li, Zhonghua, Sun, Kai, Fu, Yundong, Cheng, Ting, Guo, Jimin, Yu, Bin, Shi, Xiaojing, Liu, Hongmin
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2020
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://ncbi.nlm.nih.gov/pubmed/32963944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.12.008
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