Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations

Cerebral cavernous malformation (CCM) is a common cerebrovascular disease that can occur sporadically or be inherited. They are major causes of stroke, cerebral hemorrhage, and neurological deficits in the younger population. Loss-of-function mutations in three genes, CCM1, CCM2, and CCM3, have been...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Choi, Jaesung P., Wang, Rui, Yang, Xi, Wang, Xian, Wang, Lu, Ting, Ka Ka, Foley, Matthew, Cogger, Victoria, Yang, Zhuo, Liu, Feng, Han, Zhiming, Liu, Renjing, Baell, Jonathan, Zheng, Xiangjian
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221540/
https://ncbi.nlm.nih.gov/pubmed/30417093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau0731
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