Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Choi, Jaesung P., Foley, Matthew, Zhou, Zinan, Wong, Weng-Yew, Gokoolparsadh, Naveena, Arthur, J. Simon C., Li, Dean Y., Zheng, Xiangjian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981389/
https://ncbi.nlm.nih.gov/pubmed/27513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160833
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