Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Choi, Jaesung P., Foley, Matthew, Zhou, Zinan, Wong, Weng-Yew, Gokoolparsadh, Naveena, Arthur, J. Simon C., Li, Dean Y., Zheng, Xiangjian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981389/
https://ncbi.nlm.nih.gov/pubmed/27513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160833
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