Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic...

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Vydáno v:PLoS One
Hlavní autoři: Choi, Jaesung P., Foley, Matthew, Zhou, Zinan, Wong, Weng-Yew, Gokoolparsadh, Naveena, Arthur, J. Simon C., Li, Dean Y., Zheng, Xiangjian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981389/
https://ncbi.nlm.nih.gov/pubmed/27513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160833
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