The cerebral cavernous malformation pathway controls embryonic endocardial gene expression through regulation of MEKK3 signaling and KLF expression

The cerebral cavernous malformation (CCM) pathway is required in endothelial cells for normal cardiovascular development and to prevent postnatal vascular malformations, but its molecular effectors are not well defined. Here we show that loss of CCM signaling in endocardial cells results in mid-gest...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Zhou, Zinan, Rawnsley, David, Goddard, Lauren, Pan, Wei, Cao, Xing-Jun, Jakus, Zoltan, Zheng, Hui, Yang, Jisheng, Arthur, Simon, Whitehead, Kevin J., Li, Dean, Zhou, Bin, Garcia, Benjamin A., Zheng, Xiangjian, Kahn, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589864/
https://ncbi.nlm.nih.gov/pubmed/25625206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.12.009
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