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Cerebral cavernous malformations arise independent of the Heart of Glass receptor
BACKGROUND AND PURPOSE: The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2 and PDCD10 in a common signaling pathway required for heart and vascular development. Mutations in KRIT1, CCM2 and PDCD10 also underlie human cerebral cavernous malformation (CCM), and postnatal loss...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4006321/ https://ncbi.nlm.nih.gov/pubmed/24643410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.114.004809 |
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