Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway

Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function, KRIT1, CCM2 and PDCD10. Here we show that the HEG1 receptor, linked to CCM genes in zebrafish, is selectively expressed in endothelial cells and that Heg1(-/-) mice exhibi...

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Detalhes bibliográficos
Main Authors: Kleaveland, Benjamin, Zheng, Xiangjian, Liu, Jian J., Blum, Yannick, Tung, Jennifer J., Zou, Zhiying, Chen, Mei, Guo, Lili, Lu, Min-min, Zhou, Diane, Kitajewski, Jan, Affolter, Markus, Ginsberg, Mark H., Kahn, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665266/
https://ncbi.nlm.nih.gov/pubmed/19151727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1918
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