Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

Cerebral cavernous malformations (CCM) are vascular malformations of the central nervous system (CNS) that lead to cerebral hemorrhages. Familial CCM occurs as an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes. Constitutive or tissue-specific ablation...

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Détails bibliographiques
Auteurs principaux: Boulday, Gwénola, Rudini, Noemi, Maddaluno, Luigi, Blécon, Anne, Arnould, Minh, Gaudric, Alain, Chapon, Françoise, Adams, Ralf H., Dejana, Elisabetta, Tournier-Lasserve, Elisabeth
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171098/
https://ncbi.nlm.nih.gov/pubmed/21859843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110571
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