Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

Cerebral cavernous malformations (CCM) are vascular malformations of the central nervous system (CNS) that lead to cerebral hemorrhages. Familial CCM occurs as an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes. Constitutive or tissue-specific ablation...

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Hauptverfasser: Boulday, Gwénola, Rudini, Noemi, Maddaluno, Luigi, Blécon, Anne, Arnould, Minh, Gaudric, Alain, Chapon, Françoise, Adams, Ralf H., Dejana, Elisabetta, Tournier-Lasserve, Elisabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171098/
https://ncbi.nlm.nih.gov/pubmed/21859843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110571
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