Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

Cerebral cavernous malformations (CCM) are vascular malformations of the brain that lead to cerebral hemorrhages. In 20% of CCM patients, this results from an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes. High expression levels of the CCM genes in t...

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Main Authors: Boulday, Gwénola, Blécon, Anne, Petit, Nathalie, Chareyre, Fabrice, Garcia, Luis A., Niwa-Kawakita, Michiko, Giovannini, Marco, Tournier-Lasserve, Elisabeth
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Limited 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650198/
https://ncbi.nlm.nih.gov/pubmed/19259391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.001263
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