Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences. At present, the only recommended treatment of CCM is surgical. Because surgery is often not applicable, pharmacol...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bravi, Luca, Rudini, Noemi, Cuttano, Roberto, Giampietro, Costanza, Maddaluno, Luigi, Ferrarini, Luca, Adams, Ralf H., Corada, Monica, Boulday, Gwenola, Tournier-Lasserve, Elizabeth, Dejana, Elisabetta, Lampugnani, Maria Grazia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500248/
https://ncbi.nlm.nih.gov/pubmed/26109568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501352112
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