Relationship between Dose, Drug Levels, and D2 Receptor Occupancy for the Atypical Antipsychotics Risperidone and Paliperidone

Por Muly, E. C., Votaw, J. R., Ritchie, J., Howell, L. L.
Publicado em 2012

The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury

Por Joshi, Nikita, Kopec, Anna K., Towery, Keara, Williams, Kurt J., Luyendyk, James P.
Publicado em 2014

Clozapine-Related EEG Changes and Seizures: Dose and Plasma-Level Relationships

Por Varma, Seema, Bishara, Delia, Besag, Frank M. C., Taylor, David
Publicado em 2011

Drug-drug interaction between isavuconazole and tacrolimus: a case report indicating the need for tacrolimus drug-level monitoring

Por Kim, Tiffany, Jancel, Timothy, Kumar, Parag, Freeman, Alexandra F.
Publicado no J Clin Pharm Ther (2015)

Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities

Por Zhang, Ran-Ran, Zheng, Yun-Wen, Li, Bin, Tsuchida, Tomonori, Ueno, Yasuharu, Nie, Yun-Zhong, Taniguchi, Hideki
Publicado no Stem Cell Res Ther (2015)

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

Por Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.
Publicado no Mol Ther Nucleic Acids (2017)

Protective Properties of 2-Acetylcyclopentanone in a Mouse Model of Acetaminophen Hepatotoxicity

Por Zhang, Lihai, Gavin, Terrence, Geohagen, Brian C., Liu, Qiang, Downey, Katherine J., LoPachin, Richard M.
Publicado em 2013

Use of glomerular filtration rate estimating equations for drug dosing in HIV-positive patients

Por Okparavero, Aghogho A, Tighiouart, Hocine, Krishnasami, Zipporah, Wyatt, Christina M, Graham, Hiba, Hellinger, James, Inker, Lesley A
Publicado em 2013

Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation

Por Hayashi, Tomoko, Crain, Brian, Yao, Shiyin, Caneda, Christa D., Cottam, Howard B., Chan, Michael, Corr, Maripat, Carson, Dennis A.
Publicado em 2014

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor

Por Kerr, Alastair G., Tam, Lawrence C. S., Hale, Ashley B., Cioroch, Milena, Douglas, Gillian, Agkatsev, Sarina, Hibbitt, Olivia, Mason, Joseph, Holt-Martyn, James, Bataille, Carole J. R., Wynne, Graham M., Channon, Keith M., Russell, Angela J., Wade-Martins, Richard
Publicado no J Pharmacol Exp Ther (2017)

Variation in dose and plasma level of lamotrigine in patients discharged from a mental health trust

Por Douglas-Hall, Petrina, Dzahini, Olubanke, Gaughran, Fiona, Bile, Ahmed, Taylor, David
Publicado no Ther Adv Psychopharmacol (2016)

New Pyripyropene A Derivatives, Highly SOAT2-Selective Inhibitors, Improve Hypercholesterolemia and Atherosclerosis in Atherogenic Mouse Models

Por Ohshiro, Taichi, Ohtawa, Masaki, Nagamitsu, Tohru, Matsuda, Daisuke, Yagyu, Hiroaki, Davis, Matthew A., Rudel, Lawrence L., Ishibashi, Shun, Tomoda, Hiroshi
Publicado no J Pharmacol Exp Ther (2015)

Super-compact treatment with a high dose of moxifloxacin in patients with drug-resistant tuberculosis and its resistance mechanisms

Por WANG, QINGJIANG, ZHANG, CHUNXIAO, GUO, JINHUI, HUANG, JIAN, XI, XIUE, ZHANG, LIGONG, CUI, XIUQIN
Publicado no Exp Ther Med (2015)

Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis

Por Doessegger, Lucette, Schmitt, Georg, Lenz, Barbara, Fischer, Holger, Schlotterbeck, Götz, Atzpodien, Elke-Astrid, Senn, Hans, Suter, Laura, Csato, Miklos, Evers, Stefan, Singer, Thomas
Publicado em 2013

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

Por Tan, Cheau Yih, Lai, Ruenn Chai, Wong, Winnie, Dan, Yock Young, Lim, Sai-Kiang, Ho, Han Kiat
Publicado no Stem Cell Res Ther (2014)

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors

Por Srivastava, Apurva K., Hollingshead, Melinda G., Govindharajulu, Jeevan P., Covey, Joseph M., Liston, Dane, Simpson, Melanie A., Peggins, James O., Bottaro, Donald P., Wright, John J., Kinders, Robert J., Doroshow, James H., Parchment, Ralph E.
Publicado no Mol Cancer Ther (2018)

Effect of varying doses of tamoxifen on ovarian histopathology, serum VEGF, and endothelin 1 levels in ovarian hyperstimulation syndrome: an experimental study

Por Pala, Şehmus, Atilgan, Remzi, Ozkan¹, Zehra Sema, Kavak, Salih Burçin, Ilhan, Nevin, Akpolat, Nusret, Sapmaz, Ekrem
Publicado no Drug Des Devel Ther (2015)

Repeated Administration of a Mutant Cocaine Esterase: Effects on Plasma Cocaine Levels, Cocaine...

Por Collins, Gregory T., Brim, Remy L., Noon, Kathleen R., Narasimhan, Diwahar, Lukacs, Nicholas W., Sunahara, Roger K., Woods, James H., Ko, Mei-Chuan
Publicado em 2012

Differential Localization of Flavin-Containing Monooxygenase (FMO) Isoforms 1, 3, and 4 in Rat Liver and Kidney and Evidence for Expression of FMO4 in Mouse, Rat, and Human Liver and Kidney...

Por Novick, Rachel M., Mitzey, Ann M., Brownfield, Mark S., Elfarra, Adnan A.
Publicado em 2009

Optimizing clopidogrel dose response: a new clinical algorithm comprising CYP2C19 pharmacogenetics and drug interactions

Por Saab, Yolande B, Zeenny, Rony, Ramadan, Wijdan H
Publicado no Ther Clin Risk Manag (2015)