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Relationship between Dose, Drug Levels, and D2 Receptor Occupancy for the Atypical Antipsychotics Risperidone and Paliperidone

Blockade of D2 family dopamine receptors (D2Rs) is a fundamental property of antipsychotics, and the degree of striatal D2R occupancy has been related to antipsychotic and motor effects of these drugs. Recent studies suggest the D2R occupancy of antipsychotics may differ in extrastriatal regions com...

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Autors principals: Muly, E. C., Votaw, J. R., Ritchie, J., Howell, L. L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310702/
https://ncbi.nlm.nih.gov/pubmed/22214649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189076
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