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The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury

Hepatic fibrin deposition has been shown to inhibit hepatocellular injury in mice exposed to the bile duct toxicant α-naphthylisothiocyanate (ANIT). Degradation of fibrin clots by fibrinolysis controls the duration and extent of tissue fibrin deposition. Thus, we sought to determine the effect of tr...

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Detalhes bibliográficos
Main Authors: Joshi, Nikita, Kopec, Anna K., Towery, Keara, Williams, Kurt J., Luyendyk, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019324/
https://ncbi.nlm.nih.gov/pubmed/24633426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.210880
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