Fibrin deposition following bile duct injury limits fibrosis through an α(M)β(2)-dependent mechanism

Coagulation cascade activation and fibrin deposits have been implicated or observed in diverse forms of liver damage. Given that fibrin amplifies pathological inflammation in several diseases through the integrin receptor α(M)β(2), we tested the hypothesis that disruption of the fibrin(ogen)-α(M)β(2...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Joshi, Nikita, Kopec, Anna K., Ray, Jessica L., Cline-Fedewa, Holly, Nawabi, Atta, Schmitt, Timothy, Nault, Rance, Zacharewski, Timothy R., Rockwell, Cheryl E., Flick, Matthew J., Luyendyk, James P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891955/
https://ncbi.nlm.nih.gov/pubmed/26921287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670703
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