Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12

BACKGROUND & AIMS: Acetaminophen (APAP)-induced liver injury is coupled to activation of the blood coagulation cascade and fibrin(ogen) accumulation within APAP-injured livers of experimental mice. We sought to define the precise role of fibrin(ogen) deposition in APAP-induced liver injury and r...

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Pubblicato in:J Hepatol
Autori principali: Kopec, Anna K., Joshi, Nikita, Cline-Fedewa, Holly, Wojcicki, Anna V., Ray, Jessica L., Sullivan, Bradley P., Froehlich, John E., Johnson, Brendan F., Flick, Matthew J., Luyendyk, James P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362307/
https://ncbi.nlm.nih.gov/pubmed/27965156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.12.004
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