Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury

Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by thrombin cleavage of fibrinogen leading to fibrin polymerization and cross-linking by factor XIIIa (FXIIIa). Extravascular fibrin(ogen) deposits are observed in injured tissues; however, the mechanisms regula...

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Bibliographic Details
Published in:Blood
Main Authors: Poole, Lauren G., Kopec, Anna K., Groeneveld, Dafna J., Pant, Asmita, Baker, Kevin S., Cline-Fedewa, Holly M., Flick, Matthew J., Luyendyk, James P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2021
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109015/
https://ncbi.nlm.nih.gov/pubmed/33569603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007415
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