Fibrin deposition following bile duct injury limits fibrosis through an α(M)β(2)-dependent mechanism

Coagulation cascade activation and fibrin deposits have been implicated or observed in diverse forms of liver damage. Given that fibrin amplifies pathological inflammation in several diseases through the integrin receptor α(M)β(2), we tested the hypothesis that disruption of the fibrin(ogen)-α(M)β(2...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Joshi, Nikita, Kopec, Anna K., Ray, Jessica L., Cline-Fedewa, Holly, Nawabi, Atta, Schmitt, Timothy, Nault, Rance, Zacharewski, Timothy R., Rockwell, Cheryl E., Flick, Matthew J., Luyendyk, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891955/
https://ncbi.nlm.nih.gov/pubmed/26921287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670703
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