Fibrin deposition following bile duct injury limits fibrosis through an α(M)β(2)-dependent mechanism

Coagulation cascade activation and fibrin deposits have been implicated or observed in diverse forms of liver damage. Given that fibrin amplifies pathological inflammation in several diseases through the integrin receptor α(M)β(2), we tested the hypothesis that disruption of the fibrin(ogen)-α(M)β(2...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Joshi, Nikita, Kopec, Anna K., Ray, Jessica L., Cline-Fedewa, Holly, Nawabi, Atta, Schmitt, Timothy, Nault, Rance, Zacharewski, Timothy R., Rockwell, Cheryl E., Flick, Matthew J., Luyendyk, James P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891955/
https://ncbi.nlm.nih.gov/pubmed/26921287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670703
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