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Hepatocyte tissue factor activates the coagulation cascade in mice

In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs) and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) overdose. TF expression was significantly reduced in isolated HPCs and liver homogenates from TF(flox/flox)/albumin-Cre mic...

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Detalhes bibliográficos
Main Authors: Sullivan, Bradley P., Kopec, Anna K., Joshi, Nikita, Cline, Holly, Brown, Juliette A., Bishop, Stephanie C., Kassel, Karen M., Rockwell, Cheryl, Mackman, Nigel, Luyendyk, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591805/
https://ncbi.nlm.nih.gov/pubmed/23305736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-455436
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