Fas-Induced Apoptosis Increases Hepatocyte Tissue Factor Procoagulant Activity In Vitro and In Vivo

Hepatocyte (HPC) apoptosis occurs in association with hepatotoxic responses and chronic liver disease, and is coupled to activation of the blood coagulation cascade. HPCs have been shown to express tissue factor (TF), the primary activator of blood coagulation, in a form that lacks procoagulant acti...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Lopez, Michelle, Kopec, Anna K., Joshi, Nikita, Geddings, Julia E., Cline, Holly, Towery, Keara L., Rockwell, Cheryl E., Mackman, Nigel, Luyendyk, James P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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116
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271044/
https://ncbi.nlm.nih.gov/pubmed/25015658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu139
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