Fas-Induced Apoptosis Increases Hepatocyte Tissue Factor Procoagulant Activity In Vitro and In Vivo

Hepatocyte (HPC) apoptosis occurs in association with hepatotoxic responses and chronic liver disease, and is coupled to activation of the blood coagulation cascade. HPCs have been shown to express tissue factor (TF), the primary activator of blood coagulation, in a form that lacks procoagulant acti...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Lopez, Michelle, Kopec, Anna K., Joshi, Nikita, Geddings, Julia E., Cline, Holly, Towery, Keara L., Rockwell, Cheryl E., Mackman, Nigel, Luyendyk, James P.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
116
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271044/
https://ncbi.nlm.nih.gov/pubmed/25015658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu139
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