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Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation

Toll-like receptor (TLR) stimulation has been implicated as a major contributor to chronic inflammation. Among these receptors, TLR4 has been described as a key regulator of endogenous inflammation and has been proposed as a therapeutic target. Previously, we discovered by high-throughput screening...

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Autori principali: Hayashi, Tomoko, Crain, Brian, Yao, Shiyin, Caneda, Christa D., Cottam, Howard B., Chan, Michael, Corr, Maripat, Carson, Dennis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109491/
https://ncbi.nlm.nih.gov/pubmed/24893985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214312
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