Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands

The Toll-like receptors (TLRs) are critical components of the innate immune system that regulate immune recognition in part through NF-κB activation. A human cell-based high throughput screen (HTS) revealed substituted 4-aminoquinazolines to be small molecular weight activators of NF-κB. The most po...

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Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Nour, Afshin, Hayashi, Tomoko, Chan, Michael, Yao, Shiyin, Tawatao, Rommel I., Crain, Brian, Tsigelny, Igor F., Kouznetsova, Valentina L., Ahmadiiveli, Alast, Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A., Cottam, Howard B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250372/
https://ncbi.nlm.nih.gov/pubmed/25288184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.039
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