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Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands
The Toll-like receptors (TLRs) are critical components of the innate immune system that regulate immune recognition in part through NF-κB activation. A human cell-based high throughput screen (HTS) revealed substituted 4-aminoquinazolines to be small molecular weight activators of NF-κB. The most po...
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| izdano v: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250372/ https://ncbi.nlm.nih.gov/pubmed/25288184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.039 |
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