Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity

Most vaccine adjuvants directly stimulate and activate antigen presenting cells but do not sustain immunostimulation of these cells. A high throughput screening (HTS) strategy was designed to identify compounds that would sustain NF-κB activation by a stimulus from the Toll-like receptor (TLR)4 liga...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Comb Sci
Prif Awduron: Chan, Michael, Ahmadi, Alast, Yao, Shiyin, Sato-Kaneko, Fumi, Messer, Karen, Pu, Minya, Nguyen, Brandon, Hayashi, Tomoko, Corr, Maripat, Carson, Dennis A., Cottam, Howard B., Shukla, Nikunj M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841913/
https://ncbi.nlm.nih.gov/pubmed/28657707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.7b00080
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